A microfluidic sensor system based on a carbon nanotube-epoxy composite electrode was fabricated to allow detection of the
presence of the anti-cancer drug carboplatin in healthy tissue in real time during chemotherapy. Detection of carboplatin was
carried out by observing the effects of the drug on the differential pulse voltammetry of free purine bases using a novel carbon
nanotube-epoxy composite electrode. In free solution these electrodes performed better than glassy carbon electrodes for oxidation
of the free purine bases AMP and GMP, and than DNA-modified carbon nanotube-epoxy composite sensors for detection of
carboplatin. On-line carboplatin detection was performed using a computer-controlled microfluidic platform. The methodology
for on-line carboplatin detection was optimised in terms of the analysis time and of to allow repeated carboplatin measurement
using the same electrode. Microdialysis sampling and our microfluidic platform were combined to give a proof of concept system
for real-time carboplatin detection with a limit of detection of 0.014 mM carboplatin in the sampled media. This paper is
dedicated to Craig Lunte’s pioneering work in analysis and microdialysis.