A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?
File(s)
Author(s)
McGonnell, Imelda M
Grigoriadis, Agamemnon E
Lam, Eric W-F
Price, Joanna S
Sunters, Andrew
Type
Journal Article
Abstract
The phosphoinositide 3-kinase and AKT (protein kinase B) signaling pathway (PI3K/AKT) plays a central role in the control of cell survival, growth, and proliferation throughout the body. With regard to bone, and particularly in osteoblasts, there is an increasing amount of evidence that the many signaling molecules exert some of their bone-specific effects in part via selectively activating some of the generic effects of the PI3K/AKT pathway in osteoblasts. There is further data demonstrating that PI3K/AKT has the capacity to specifically cross-talk with other signaling pathways and transcriptional networks controlling bone cells' development in order to fine-tune the osteoblast phenotype. There is also evidence that perturbations in the PI3K/AKT pathway may well be responsible for certain bone pathologies. In this review, we discuss some of these findings and suggest that the PI3K/AKT pathway is a central nexus in the extensive network of extracellular signaling pathways that control the osteoblast.
Date Issued
2012-07-20
Date Acceptance
2012-06-29
Citation
Frontiers in Endocrinology, 2012, 3
ISSN
1664-2392
Publisher
Frontiers Media
Journal / Book Title
Frontiers in Endocrinology
Volume
3
Copyright Statement
© 2012 McGonnell, Grigoriadis, Lam, Price and Sunters. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/22833734
Subjects
AKT
PI3K
osteoblast
phosphoinositide 3-kinase
protein kinase B
Publication Status
Published
Coverage Spatial
Switzerland
Article Number
ARTN 88