Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients
Author(s)
Type
Journal Article
Abstract
SIGNIFICANCE: Intracranial pressure (ICP), variability in perfusion, and resulting ischemia are leading causes of secondary brain injury in patients treated in the neurointensive care unit. Continuous, accurate monitoring of cerebral blood flow (CBF) and ICP guide intervention and ultimately reduce morbidity and mortality. Currently, only invasive tools are used to monitor patients at high risk for intracranial hypertension. AIM: Diffuse correlation spectroscopy (DCS), a noninvasive near-infrared optical technique, is emerging as a possible method for continuous monitoring of CBF and critical closing pressure (CrCP or zero-flow pressure), a parameter directly related to ICP. APPROACH: We optimized DCS hardware and algorithms for the quantification of CrCP. Toward its clinical translation, we validated the DCS estimates of cerebral blood flow index (CBFi) and CrCP in ischemic stroke patients with respect to simultaneously acquired transcranial Doppler ultrasound (TCD) cerebral blood flow velocity (CBFV) and CrCP. RESULTS: We found CrCP derived from DCS and TCD were highly linearly correlated (ipsilateral R2 = 0.77, p = 9 × 10 - 7; contralateral R2 = 0.83, p = 7 × 10 - 8). We found weaker correlations between CBFi and CBFV (ipsilateral R2 = 0.25, p = 0.03; contralateral R2 = 0.48, p = 1 × 10 - 3) probably due to the different vasculature measured. CONCLUSION: Our results suggest DCS is a valid alternative to TCD for continuous monitoring of CrCP.
Date Issued
2021-03-27
Date Acceptance
2021-03-08
Citation
Journal of Biomedical Optics, 2021, 26 (3), pp.036008-1-036008-14
ISSN
1083-3668
Publisher
Society of Photo-optical Instrumentation Engineers
Start Page
036008-1
End Page
036008-14
Journal / Book Title
Journal of Biomedical Optics
Volume
26
Issue
3
Copyright Statement
© The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/33774980
PII: JBO-200360R
Subjects
critical closing pressure
diffuse correlation spectroscopy
intracranial pressure
ischemic stroke
near-infrared spectroscopy
Publication Status
Published
Coverage Spatial
United States
Article Number
036008
Date Publish Online
2021-03-27