A systematic review of randomised controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
The clinical sequelae of oestrogen deficiency during menopause are undoubted. However, the pathophysiological role of testosterone during the menopause is less clear. Several randomised, placebo-controlled clinical trials suggest that testosterone therapy improves sexual function in post-menopausal women. Some studies suggest that testosterone therapy has additional effects which include increased bone mineral density and decreased serum high density lipoprotein (HDL) cholesterol. Furthermore, the long-term safety profile of testosterone therapy in post-menopausal women is not clear. This article will provide a concise and critical summary of the literature, to guide clinicians treating post-menopausal women. This article is protected by copyright. All rights reserved.
Date Issued
2019-03
Date Acceptance
2018-11-22
Citation
Clinical Endocrinology, 2019, 90 (3), pp.391-414
ISSN
1365-2265
Publisher
Wiley
Start Page
391
End Page
414
Journal / Book Title
Clinical Endocrinology
Volume
90
Issue
3
Copyright Statement
© 2018 John Wiley & Sons Ltd. This is the accepted version of the following article: Jayasena, CN, Alkaabi, FM, Liebers, CS, Handley, T, Franks, S, Dhillo, WS. A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women. Clin Endocrinol (Oxf). 2019; 90: 391– 414, which has been published in final form at https://doi.org/10.1111/cen.13906
Sponsor
National Institute for Health Research
Medical Research Council (MRC)
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/30488972
Grant Number
PDF-2017-10-098
G0802782
Subjects
Androgen
Libido
Menopause
Safety
Sexual Dysfunction
Testosterone
Women
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2018-11-29