Molecular phenomic approaches to deconvolving the systemic effects of SARS-CoV-2 infection and post-acute COVID-19 syndrome
Author(s)
Nicholson, Jeremy K
Type
Journal Article
Abstract
SARS COV-2 infection causes acute and frequently severe respiratory disease with associated multi-organ damage and systemic disturbances in many biochemical pathways. Metabolic phenotyping provides deep insights into the complex immunopathological problems that drive the resulting COVID-19 disease and is also a source of novel metrics for assessing patient recovery. A multiplatform metabolic phenotyping approach to studying the pathology and systemic metabolic sequelae of COVID-19 is considered here, together with a framework for assessing post-acute COVID-19 Syndrome (PACS) that is a major long-term health consequence for many patients. The sudden emergence of the disease presents a biological discovery challenge as we try to understand the pathological mechanisms of the disease and develop effective mitigation strategies. This requires technologies to measure objectively the extent and sub-phenotypes of the disease at the molecular level. Spectroscopic methods can reveal metabolic sub-phenotypes and new biomarkers that can be monitored during the acute disease phase and beyond. This approach is scalable and translatable to other pathologies and provides as an exemplar strategy for the investigation of other emergent zoonotic diseases with complex immunological drivers, multi-system involvements and diverse persistent symptoms.
Date Issued
2021-08-01
Date Acceptance
2021-06-17
Citation
Phenomics, 2021, 1 (4), pp.143-150
ISSN
2730-583X
Publisher
Springer
Start Page
143
End Page
150
Journal / Book Title
Phenomics
Volume
1
Issue
4
Copyright Statement
© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/35233558
PII: 20
Subjects
COVID-19
Genetics & Heredity
Life Sciences & Biomedicine
Metabolic Phenoconversion
Phenoreversion
Post-acute COVID-19 Syndrome (PACS)
REVEALS
SARS COV-2
Science & Technology
Spectroscopy
Publication Status
Published
Coverage Spatial
Switzerland
Date Publish Online
2021-07-22