One anastomosis gastric bypass produces considerable weight reduction and resolution of medical complications with an acceptable rate of nutritional deficiencies
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
One anastomosis gastric bypass (OAGB) is a relatively novel bypass surgery variant, increasingly used as a primary surgical procedure. A total of 101 patients (mean age 44.7 ± 10.7 years, mean BMI 47.2 ± 6.6 kg/m2) underwent OAGB between 2014 and 2019 in a single institution. Results obtained 6,12 and 24 months postoperatively were compared with the pre-operative values using “Analyse-it software v5.40.2” and Graphpad Prism v9.3 for figures and tables. Data were tested for normality, described as Mean ± SD, compared using paired sample t-test with 5% p-value for significance and 95% confidence interval (CI). A significant body mass index (BMI), haemoglobin A1c (HbA1c) and low-density lipoprotein (LDL) reduction was recorded throughout follow-up period, with greatest improvement seen 2 years after surgery (47.6 ± 22 kg/m2 vs. 29.4 ± 6.4 kg/m2 ,6.7 ± 1.8% vs. 5.5 ± 0.2% and 3.2 ± 1 vs. 2.05 + 0.7 mmol/ l, p < 0.05). The number of glucose-lowering drugs decreased from 1.6 ± 0.9 to 0.3 ± 0.4 at 24-months, p < 0.001. The rates for zinc, ferritin, folate, B12 and vitamin D deficiency at 24-months were: 8.9%,4%, 5.9%, 0% and 3% respectively. OAGB can effectively downstage obesity disease and improve glucose and lipid homeostasis with a low risk for nutritional deficiencies. This study is one of few to report specifically on the frequency and type of nutritional deficiencies following OAGB surgery.
Date Issued
2025-08-17
Date Acceptance
2025-07-21
Citation
Scientific Reports, 2025, 15
ISSN
2045-2322
Publisher
Nature Portfolio
Start Page
30106
Journal / Book Title
Scientific Reports
Volume
15
Issue
1
Copyright Statement
© The Author(s) 2025 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/40820145
PII: 10.1038/s41598-025-12997-2
Subjects
Bariatric surgery
Hyperlipidaemia
Nutritional deficiency
Obesity
Obstructive sleep apnoea
One anastomosis gastric bypass
T2DM
Humans
Gastric Bypass
Female
Male
Adult
Middle Aged
Weight Loss
Body Mass Index
Obesity, Morbid
Glycated Hemoglobin
Postoperative Complications
Malnutrition
Treatment Outcome
Publication Status
Published
Coverage Spatial
England
Article Number
30106
Date Publish Online
2025-08-17