Faecal (or intestinal) microbiota transplant: a tool for repairing the gut microbiome
File(s)
Author(s)
Type
Journal Article
Abstract
Faecal/ intestinal microbiota transplant (FMT/ IMT) is an efficacious treatment option for recurrent Clostridioides difficile infection, which has prompted substantial interest in FMT’s potential role in the management of a much broader range of diseases associated with the gut microbiome. Despite its promise, the success rates of FMT have been variable. This review critically evaluates the current evidence on the effect of clinical, biological and procedural factors on the therapeutic efficacy of FMT, and identifies areas that remain nebulous. Due to some of these factors, the optimal therapeutic approach remains unclear; for example, the timing of FMT administration in a heavily antibiotic-exposed haematopoietic cell transplant recipient is not standardised, with arguments that can be made in alternate directions. We explore how these factors may impact upon more informed selection of donors, potential matching of donors to recipients, and aspects of clinical care of FMT recipients. This includes consideration of how gut microbiome composition and functionality may strategically inform donor selection criteria. Furthermore, we review how the most productive advances within the FMT space are those where clinical and translational outcomes are assessed together, and where this model has been used productively in recent years to better understand the contribution of the gut microbiome to human disease, and start the process towards development of more targeted microbiome therapeutics.
Date Issued
2024
Date Acceptance
2024-10-24
Citation
Gut Microbes, 2024, 16 (1)
ISSN
1949-0976
Publisher
Taylor & Francis Group
Journal / Book Title
Gut Microbes
Volume
16
Issue
1
Copyright Statement
© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted
Manuscript in a repository by the author(s) or with their consent.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted
Manuscript in a repository by the author(s) or with their consent.
License URL
Identifier
https://www.tandfonline.com/doi/full/10.1080/19490976.2024.2423026
Publication Status
Published
Article Number
2423026
Date Publish Online
2024-11-05