Objectives. To identify the risk factors for poor eye drop application technique in treatment-na¨ıve subjects and to assess if patient
education can benefit these subjects. Methods. Chinese subjects above 60 years were recruited. Questionnaires, including Barthel
index; Lawton’s instrumental activities of daily living (ADL); Fatigue, Resistance, Ambulation, Illnesses, and Loss of Weight
(FRAIL) scale; and Montreal Cognitive Assessment (MoCA), were used to correlate with eye drop application technique (before
and after patient education) using Spearman correlation analysis. A multiple linear regression was conducted to determine the
predictors of successful administration technique and the improvement of technique after education. Results. /e data from 26
subjects (mean age 72) were analyzed. Eye drop instillation technique score improved from 5.42 at baseline to 7.33 after clear
instructions. FRAIL score was an independent predictor of baseline score (p � 0.003), as well as the improvement after patient
education (p � 0.012). Age, sex, education level, visual acuity, Barthel index, MoCA, and ADL score were not correlated with eye
drop instillation technique, before nor after patient education. Discussion. In patients with poor functional status as reflected by
FRAIL score, eye drop application is prone to be ineffective. Education with step-by-step instructions could effectively improve the
success of eye drop application.