Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation.
Author(s)
Sturrock, M
Hellander, A
Matzavinos, A
Chaplain, MA
Type
Journal Article
Abstract
Individual mouse embryonic stem cells have been found to exhibit highly variable differentiation responses under the same environmental conditions. The noisy cyclic expression of Hes1 and its downstream genes are known to be responsible for this, but the mechanism underlying this variability in expression is not well understood. In this paper, we show that the observed experimental data and diverse differentiation responses can be explained by a spatial stochastic model of the Hes1 gene regulatory network. We also propose experiments to control the precise differentiation response using drug treatment.
Date Issued
2013-03-06
Citation
Journal of the Royal Society Interface, 2013, 10 (80)
ISSN
1742-5689
Publisher
The Royal Society
Journal / Book Title
Journal of the Royal Society Interface
Volume
10
Issue
80
Copyright Statement
© 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.
License URL
Identifier
http://www.ncbi.nlm.nih.gov/pubmed/23325756
PII: rsif.2012.0988
Subjects
Animals
Basic Helix-Loop-Helix Transcription Factors
Cell Differentiation
Embryonic Stem Cells
Gene Expression Regulation
Homeodomain Proteins
Mice
Models, Biological
Stochastic Processes
Coverage Spatial
England