Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency
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Published version
Author(s)
Type
Journal Article
Abstract
Background. Treatment of chronic cough remains a challenge. We hypothesized that inhaled alkaline hypertonic divalent salts (alkaline HDS) might provide relief for refractory chronic cough by laryngeal and tracheal hydration. Methods. We conducted an exploratory, single-blinded, nasal-saline-controlled study in 12 refractory chronic cough patients to examine cough-suppression efficacy of an alkaline HDS composition (SC001) at pH 8 or pH 9 administered by nasal inhalation. As control, we used nasal saline with the same hand-held pump spray aerosol device. Each subject was monitored continuously using a digital cough monitor watch for one week of baseline, one week of control treatment, and one week of active treatment. Results. Baseline daily cough rates ranged from 4 to 34 coughs/hour with mean visual analog score 65±17 pre- and post-baseline testing. Control-adjusted efficacy of cough rate reduction ranged from 15% (p=0.015) (from Day 1) to 23% (p=0.002) (from Day 3). Control-adjusted efficacy was highest with SC001 pH 9 (n=5), ranging from 25% (p=0.03) (from Day 1) to 35% (p=0.02) (from Day 3), and lowest for SC001 pH 8 (n=7), ranging from 9% (p=0.08) (from Day 1) to 16% (p=0.02) (from Day 3). Hourly cough counts and VAS correlated for baseline (r=0.254, p-value=0.02) and control (r=0.299, p-value=0.007) monitoring weeks. Treatment improved this correlation (r=0.434, p-value=0.00006). No adverse events were reported. Conclusions. Alkaline (pH 9) HDS aerosol is a promising treatment for refractory chronic cough and should be further evaluated.
Date Issued
2024-10-07
Date Acceptance
2024-04-26
ISSN
2312-0541
Publisher
European Respiratory Society
Journal / Book Title
ERJ Open Research
Volume
10
Issue
5
Copyright Statement
Copyright ©The authors 2024. This version is distributed under the terms of the Creative Commons
Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact
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Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact
permissions@ersnet.org
Identifier
https://openres.ersjournals.com/content/early/2024/05/16/23120541.00241-2024
Publication Status
Published
Article Number
ARTN 00241
Date Publish Online
2024-07-04