Stochastic model of protein receptor trafficking prior to synaptogenesis
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Published version
Author(s)
Bressloff, Paul C
Type
Journal Article
Abstract
We present a stochastic model of NMDA N-methyl d-aspartate receptor transport along a dendrite prior to
synapse formation. Receptors undergo periods of intracellular kinesin motor-driven transport along microtubules interspersed with periods of cycling to the cell surface through exocytosis or endocytsosis. The stochastic
dynamics is reduced to a spatially discrete hopping model that determines the time-dependent distribution of
receptors along the dendrite. We also investigate how possible defects in motor-assisted transport can affect this
distribution.
synapse formation. Receptors undergo periods of intracellular kinesin motor-driven transport along microtubules interspersed with periods of cycling to the cell surface through exocytosis or endocytsosis. The stochastic
dynamics is reduced to a spatially discrete hopping model that determines the time-dependent distribution of
receptors along the dendrite. We also investigate how possible defects in motor-assisted transport can affect this
distribution.
Date Issued
2006-09
Date Acceptance
2006-09-01
Citation
Physical Review E, 2006, 74 (3)
ISSN
1539-3755
Publisher
American Physical Society (APS)
Journal / Book Title
Physical Review E
Volume
74
Issue
3
Copyright Statement
©2006 American Physical Society
Identifier
http://dx.doi.org/10.1103/physreve.74.031910
Publication Status
Published
Article Number
031910
Date Publish Online
2006-09-22