Oxygen gradient ektacytometry does not predict pain in children with sickle cell anaemia
File(s)
Author(s)
Type
Journal Article
Abstract
The loss of red blood cell (RBC) deformability in sickle cell anaemia (SCA) is considered the primary factor responsible for episodes of acute pain and downstream progressive organ dysfunction. Oxygen gradient ektacytometry (Oxygenscan) is a recently commercialised functional assay that aims to describe the deformability of RBCs in SCA at differing oxygen tensions. So far, the Oxygenscan has been evaluated only by a small number of research groups and the validity and clinical value of Oxygenscan-derived biomarkers have not yet been fully established. In this study we examined RBC deformability measured with the Oxygenscan in 91 children with SCA at King’s College Hospital in London. We found a significant correlation between Oxygenscan-derived biomarkers and well-recognised modifiers of disease severity in SCA: haemoglobin F and co-inherited α-thalassaemia. We failed, however, to find any independent predictive value of the Oxygenscan in the clinical outcome measure of pain, as well as other important parameters such as hydroxycarbamide treatment. Although the Oxygenscan remains an intriguing tool for basic research, our results question whether it provides any additional information in predicting the clinical course in children with SCA, beyond measuring known markers of disease severity.
Date Issued
2022-06-01
Date Acceptance
2021-11-15
Citation
British Journal of Haematology, 2022, 197 (5), pp.609-617
ISSN
0007-1048
Publisher
Wiley
Start Page
609
End Page
617
Journal / Book Title
British Journal of Haematology
Volume
197
Issue
5
Copyright Statement
© 2021 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Sponsor
Wellcome Trust
Grant Number
202800/Z/16/Z
Subjects
Science & Technology
Life Sciences & Biomedicine
Hematology
sickle cell anaemia
red blood cell deformability
clinical trials
hydroxycarbamide
alpha-thalassaemia
ALPHA-THALASSEMIA
DEFORMABILITY
CRISIS
clinical trials
hydroxycarbamide
red blood cell deformability
sickle cell anaemia
α-thalassaemia
Anemia, Sickle Cell
Biomarkers
Child
Erythrocyte Deformability
Humans
Oxygen
Pain
Humans
Pain
Anemia, Sickle Cell
Oxygen
Erythrocyte Deformability
Child
Biomarkers
Immunology
1102 Cardiorespiratory Medicine and Haematology
Publication Status
Published
Date Publish Online
2021-12-03