Evaluating the Effects of Canagliflozin on Cardiovascular and Renal Events in Patients With Type 2 Diabetes Mellitus and Chronic Kidney Disease According to Baseline HbA1c, Including Those With HbA1c <7%: Results From the CREDENCE Trial
File(s)CREDENCE baseline HbgA1.pdf (95 KB)
Accepted version
Author(s)
Type
Journal Article
Abstract
Traditional management of diabetes mellitus has focused on glycemic control, beginning with lifestyle changes, followed by metformin, and then other classes of antiglycemic agents.1 Sodium glucose co-transporter 2 (SGLT2) inhibitors reduce cardiovascular (CV) events, including CV death, myocardial infarction (MI) and heart failure, and slow progression of renal dysfunction, including prevention of end-stage kidney disease (ESKD).2-3 Because initial clinical trials included mostly patients with baseline HbA1c >7%, current guidelines have recommended this class as add-on therapy for patients whose HbA1c is not at goal, typically ≥7%.1 We hypothesized that there would be similar benefits on CV and renal endpoints regardless of baseline HbA1c, including those with HbA1c <7%.
Date Issued
2020-02-04
Date Acceptance
2019-10-29
Citation
Circulation, 2020, 141 (5), pp.407-410
ISSN
0009-7322
Publisher
American Heart Association
Start Page
407
End Page
410
Journal / Book Title
Circulation
Volume
141
Issue
5
Copyright Statement
© 2019 American Heart Association, Inc.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31707795
Subjects
SGLT2 inhibitors
canagliflozin
chronic kidney disease
diabetes mellitus, type 2
Cardiovascular System & Hematology
1103 Clinical Sciences
1102 Cardiorespiratory Medicine and Haematology
1117 Public Health and Health Services
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2019-11-11