Evolution pathways of IgE responses to grass and mite allergens throughout childhood
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
BACKGROUND: Little is known about longitudinal patterns of the development of IgE to distinct allergen components. OBJECTIVE: We sought to investigate the evolution of IgE responses to allergenic components of timothy grass and dust mite during childhood. METHODS: In a population-based birth cohort (n = 1184) we measured IgE responses to 15 components from timothy grass and dust mite in children with available samples at 3 time points (ages 5, 8, and 11 years; n = 235). We designed a nested, 2-stage latent class analysis to identify cross-sectional sensitization patterns at each follow-up and their longitudinal trajectories. We then ascertained the association of longitudinal trajectories with asthma, rhinitis, eczema, and lung function in children with component data for at least 2 time points (n = 534). RESULTS: Longitudinal latent class analysis revealed 3 grass sensitization trajectories: (1) no/low sensitization; (2) early onset; and (3) late onset. The early-onset trajectory was associated with asthma and diminished lung function, and the late-onset trajectory was associated with rhinitis. Four longitudinal trajectories emerged for mite: (1) no/low sensitization; (2) group 1 allergens; (3) group 2 allergens; and (3) complete mite sensitization. Children in the complete mite sensitization trajectory had the highest odds ratios (ORs) for asthma (OR, 7.15; 95% CI, 3.80-13.44) and were the only group significantly associated with comorbid asthma, rhinitis, and eczema (OR, 5.91; 95% CI, 2.01-17.37). Among children with wheezing, those in the complete mite sensitization trajectory (but not other longitudinal mite trajectories) had significantly higher risk of severe exacerbations (OR, 3.39; 95% CI, 1.62-6.67). CONCLUSIONS: The nature of developmental longitudinal trajectories of IgE responses differed between grass and mite allergen components, with temporal differences (early vs late onset) dominant in grass and diverging patterns of IgE responses (group 1 allergens, group 2 allergens, or both) in mite. Different longitudinal patterns bear different associations with clinical outcomes, which varied by allergen.
Date Issued
2015-05-08
Date Acceptance
2015-03-20
Citation
Journal of Allergy and Clinical Immunology, 2015, 136 (6), pp.1645-1652.e8
ISSN
1097-6825
Publisher
Elsevier
Start Page
1645
End Page
1652.e8
Journal / Book Title
Journal of Allergy and Clinical Immunology
Volume
136
Issue
6
Copyright Statement
© 2015 The Authors. Published by Elsevier Inc. on behalf of the American Academy
of Allergy, Asthma & Immunology. This is an open access article under the CC BY-NC-ND
license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
of Allergy, Asthma & Immunology. This is an open access article under the CC BY-NC-ND
license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Subjects
IgE
allergens
asthma
childhood
component-resolved diagnostics
dust mite
latent class analysis
rhinitis
timothy grass
wheeze
Allergens
Animals
Child
Child, Preschool
Cohort Studies
Female
Forced Expiratory Volume
Great Britain
Humans
Hypersensitivity
Immunoglobulin E
Infant
Male
Mites
Nitric Oxide
Phleum
Vital Capacity
Allergy
1107 Immunology
Publication Status
Published