A role for Dicer in immune regulation
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Micro RNAs (miRNAs) regulate gene expression at the posttranscriptional level. Here we show that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T cells. A partial T reg cell-like miRNA profile is conferred by the enforced expression of Foxp3 and, surprisingly, by the activation of conventional CD4 T cells. Depleting miRNAs by eliminating Dicer, the RNAse III enzyme that generates functional miRNAs, reduces T reg cell numbers and results in immune pathology. Dicer facilitates, in a cell-autonomous fashion, the development of T reg cells in the thymus and the efficient induction of Foxp3 by transforming growth factor beta. These results suggest that T reg cell development involves Dicer-generated RNAs.
Date Issued
2006-10-23
Date Acceptance
2006-09-25
Citation
Journal of Experimental Medicine, 2006, 203 (11), pp.2519-2527
ISSN
0022-1007
Publisher
Rockefeller University Press
Start Page
2519
End Page
2527
Journal / Book Title
Journal of Experimental Medicine
Volume
203
Issue
11
Copyright Statement
© 2006 Rockefeller University Press.
Sponsor
Medical Research Council (MRC)
Identifier
PII: jem.20061692
Grant Number
PO4050659629
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Medicine, Research & Experimental
Research & Experimental Medicine
TRANSCRIPTION FACTOR FOXP3
T-CELL DEVELOPMENT
MICROPROCESSOR COMPLEX
LINEAGE CHOICE
TGF-BETA
MICRORNAS
DIFFERENTIATION
TARGETS
MOUSE
INDUCTION
Animals
Cell Differentiation
Cells, Cultured
Forkhead Transcription Factors
Mice
MicroRNAs
Ribonuclease III
T-Lymphocytes, Regulatory
Thymus Gland
Transforming Growth Factor beta
Thymus Gland
Cells, Cultured
Animals
Mice
Ribonuclease III
Transforming Growth Factor beta
MicroRNAs
Cell Differentiation
T-Lymphocytes, Regulatory
Forkhead Transcription Factors
11 Medical and Health Sciences
Immunology
Coverage Spatial
United States
Date Publish Online
2006-10-23