The effect of new oral anticoagulants and extended thromboprophylaxis policy on hip and knee arthroplasty outcomes: observational study
Author(s)
Bottle, A
Oragui, E
Pinder, E
Aylin, P
Loeffler, M
Type
Journal Article
Abstract
The efficacy and safety of the new oral anticoagulants (NOAC) and the benefits of extended duration thromboprophylaxis following hip and knee replacements remain uncertain. This observational study describes the relations between thromboprophylaxis policies following hip and knee replacements across England's NHS and patient outcomes between January 2008 and December 2011. From the national administrative database, we analyzed mortality, thromboembolic complications, emergency readmission, and bleeding rates for 201,418 hip and 230,282 knee replacements. There were no differences in outcomes for either LMWH or NOAC. We found no advantage in favor of any single anticoagulation policy or in changing policy. This study supports the American Academy of Orthopaedic Surgeons' recommendation that the choice and duration of thromboprophylaxis prophylaxis be decided by the treating surgeon.
Date Issued
2015-10-21
Date Acceptance
2015-03-02
Citation
Arthroplasty Today, 2015, 1 (2), pp.45-50
ISSN
2352-3441
Publisher
Elsevier
Start Page
45
End Page
50
Journal / Book Title
Arthroplasty Today
Volume
1
Issue
2
Copyright Statement
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
Publication Status
Published