Inflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
File(s)Jakszyn_Inflamm potential diet and CRC_IJC.pdf (1.97 MB)
Accepted version
Author(s)
Type
Journal Article
Abstract
Pro-inflammatory diets are associated with risk of developing colorectal cancer (CRC), however inconsistencies exist in subsite- and sex-specific associations. The relationship between CRC and combined lifestyle-related factors that contribute towards a low-grade inflammatory profile has not yet been explored. We examined the association between the dietary inflammatory potential and an inflammatory profile and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. This cohort included 476,160 participants followed-up of 14 years and 5,991 incident CRC cases (3,897 colon and 2,094 rectal tumours). Dietary inflammatory potential was estimated using an Inflammatory Score of the Diet (ISD). An Inflammatory Profile Score (IPS) was constructed, incorporating the ISD, physical activity level and abdominal obesity. The associations between the ISD and CRC and IPS and CRC were assessed using multivariable regression models. More pro- inflammatory diets were related to a higher CRC risk, particularly for colon cancer; Hazar Ratio (HR) for highest versus lowest ISD quartile was 1.15 (95% confidence interval (CI) 1.04-1.27) for CRC, 1.24 (95% CI 1.09-1.41) for colon cancer and 0.99 (95% CI 0.83-1.17) for rectal cancer. Associations were more pronounced in men and not significant in women. The IPS was associated with CRC risk, particularly colon cancer among men; HRs for the highest versus lowest IPS were 1.62 (95% CI 1.31- 2.01) for colon cancer overall and 2.11 (95% CI 1.50-2.97) for colon cancer in men. This study shows that more pro-inflammatory diets and a more inflammatory profile are associated with higher risk of CRC, principally colon cancer and in men. This article is protected by copyright. All rights reserved.
Date Issued
2020-08-15
Date Acceptance
2019-12-12
Citation
International Journal of Cancer, 2020, 147 (4), pp.1027-1039
ISSN
0020-7136
Publisher
Wiley
Start Page
1027
End Page
1039
Journal / Book Title
International Journal of Cancer
Volume
147
Issue
4
Copyright Statement
This article is protected by copyright. All rights reserved.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31945199
Subjects
Europe
Inflammatory potential of the diet
association
colorectal cancer
epidemiology
prospective cohort
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2020-01-16