Transporter oligomerisation: roles in structure and function
File(s)
Published version
Author(s)
Cecchetti, Cristina
Pyle, Euan
Byrne, Bernadette
Type
Journal Article
Abstract
Oligomerisation is a key feature of integral membrane transporters with roles in structure, function and stability. In this review, we cover some very recent advances in our understanding of how oligomerisation affects these key transporter features, with emphasis on a few groups of transporters, including the nucleobase ascorbate transporters, neurotransmitter sodium symporters and major facilitator superfamily members.
Date Issued
2019-02
Date Acceptance
2018-11-15
Citation
Biochemical Society Transactions, 2019, 47 (1), pp.433-440
ISSN
0300-5127
Publisher
Portland Press
Start Page
433
End Page
440
Journal / Book Title
Biochemical Society Transactions
Volume
47
Issue
1
Copyright Statement
© 2018 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under theCreative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/)
Sponsor
Biotechnology and Biological Sciences Research Council (BBSRC)
Biotechnology and Biological Sciences Research Council (BBSRC)
Grant Number
BB/K017292/1
BB/N016467/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
X-RAY STRUCTURES
BILE-ACID
DOPAMINE TRANSPORTER
CRYSTAL-STRUCTURE
GLUCOSE TRANSPORTERS
ELEVATOR MECHANISM
MEMBRANE-PROTEIN
RECOGNITION
BINDING
NEUROTRANSMITTER
function
membrane lipid
oligomerisation
protein structure
transporter
Ascorbic Acid
Membrane Transport Proteins
Neurotransmitter Agents
Polymerization
Ascorbic Acid
Membrane Transport Proteins
Neurotransmitter Agents
Polymerization
Biochemistry & Molecular Biology
0601 Biochemistry and Cell Biology
1101 Medical Biochemistry and Metabolomics
Publication Status
Published
Date Publish Online
2018-12-21