Fluorescence sensing technologies for ophthalmic diagnosis
File(s)acssensors.2c00313.pdf (11.15 MB)
Published version
Author(s)
Shi, Y
Hu, Y
Jiang, N
Yetisen, AK
Type
Journal Article
Abstract
Personalized and point-of-care (POC) diagnoses are critical for ocular physiology and disease diagnosis. Real-time monitoring and continuous sampling abilities of tear fluid and user-friendliness have become the key characteristics for the applied ophthalmic techniques. Fluorescence technologies, as one of the most popular methods that can fulfill the requirements of clinical ophthalmic applications for optical sensing, have been raised and applied for tear sensing and diagnostic platforms in recent decades. Wearable sensors in this case have been increasingly developed for ocular diagnosis. Contact lenses, as one of the commercialized and popular tools for ocular dysfunction, have been developed as a platform for fluorescence sensing in tears diagnostics and real-time monitoring. Numbers of biochemical analytes have been examined through developed fluorescent contact lens sensors, including pH values, electrolytes, glucose, and enzymes. These sensors have been proven for monitoring ocular conditions, enhancing and detecting medical treatments, and tracking efficiency of related ophthalmic surgeries at POC settings. This review summarizes the applied ophthalmic fluorescence sensing technologies in tears for ocular diagnosis and monitoring. In addition, the cooperation of fabricated fluorescent sensor with mobile phone readout devices for diagnosing ocular diseases with specific biomarkers continuously is also discussed. Further perspectives for the developments and applications of fluorescent ocular sensing and diagnosing technologies are also provided.
Date Issued
2022-05-31
Date Acceptance
2022-05-17
ISSN
2379-3694
Publisher
American Chemical Society
Journal / Book Title
ACS Sensors
Volume
7
Issue
6
Copyright Statement
© 2022 The Authors. Published by American Chemical Society. This article is open access under a CC-BY Attribution License 4.0 (https://creativecommons.org/licenses/by/4.0/)
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (EPSRC)
Identifier
https://pubs.acs.org/doi/10.1021/acssensors.2c00313
https://www.ncbi.nlm.nih.gov/pubmed/35640088
Grant Number
EP/T013567/1
EP/T013567/1
Subjects
Contact lens sensors
Fluorescence biosensing
Fluorescence imaging
Fluorescent tear diagnosis
Ocular diseases
Ophthalmological diagnostics
Point-of-Care
Smartphone readout devices
Tear monitoring
Biosensing Techniques
Contact Lenses
Electrolytes
Glucose
Tears
Tears
Electrolytes
Glucose
Biosensing Techniques
Contact Lenses
Contact lens sensors
Fluorescence biosensing
Fluorescence imaging
Fluorescent tear diagnosis
Ocular diseases
Ophthalmological diagnostics
Point-of-Care
Smartphone readout devices
Tear monitoring
0301 Analytical Chemistry
0903 Biomedical Engineering
1007 Nanotechnology
Publication Status
Published online
Coverage Spatial
United States
Date Publish Online
2022-05-31