Objective: To assess the safety and efficiency of cell therapy
for pseudarthrosis. Implant of the bone marrow aspirate was
compared to mononuclear cells purified extemporaneously using the Sepax® equipment. Methods: Six patients with nonunion
of the tibia or femur were treated. Four received a percutaneous
infusion of autologous bone marrow aspirated from the iliac
crest, and two received autologous bone marrow mononuclear
cells separated from the aspirate with the Sepax®. The primary
fixation method was unchanged, and the nonunion focus was
not exposed. Physical examination and radiographies were
performed 2, 4 and 6 months after the treatment by the same
physician. After consolidation of the fracture the satisfaction