Exploiting genomics for antimicrobial resistance surveillance at One Health interfaces

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1-s2.0-S2666524723002847-main.pdf (279.33 KB)

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OA Location

https://doi.org/10.1016/S2666-5247(23)00284-7

Author(s)

Muloi, Dishon M

Jauneikaite, Elita

Anjum, Muna F

Essack, Sabiha Y

Singleton, David A

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Type

Journal Article

Abstract

The intersection of human, animal, and ecosystem health at One Health interfaces is recognised as being of key importance in the evolution and spread of antimicrobial resistance (AMR) and represents an important, and yet rarely realised opportunity to undertake vital AMR surveillance. A working group of international experts in pathogen genomics, AMR, and One Health convened to take part in a workshop series and online consultation focused on the opportunities and challenges facing genomic AMR surveillance in a range of settings. Here we outline the working group's discussion of the potential utility, advantages of, and barriers to, the implementation of genomic AMR surveillance at One Health interfaces and propose a series of recommendations for addressing these challenges. Embedding AMR surveillance at One Health interfaces will require the development of clear beneficial use cases, especially in low-income and middle-income countries. Evidence of directionality, risks to human and animal health, and potential trade implications were also identified by the working group as key issues. Addressing these challenges will be vital to enable genomic surveillance technology to reach its full potential for assessing the risk of transmission of AMR between the environment, animals, and humans at One Health interfaces.

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Date Issued

2023-12-01

Date Acceptance

2023-11-01

Citation

The Lancet Microbe, 2023, 4 (12), pp.E1056-E1062

URI

https://hdl.handle.net/10044/1/120250

DOI

https://www.dx.doi.org/10.1016/S2666-5247(23)00284-7

ISSN

2666-5247

Publisher

Elsevier

Start Page

E1056

End Page

E1062

Journal / Book Title

The Lancet Microbe

Volume

4

Issue

12

Copyright Statement

© 2023 The Author(s). Published by Elsevier Ltd. This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).

License URL

https://creativecommons.org/licenses/by/4.0/

Subjects

ANIMALS

ANTIBIOTIC-RESISTANCE

CAMPYLOBACTERIOSIS

EPIDEMIOLOGY

ESCHERICHIA-COLI ST131

Infectious Diseases

Life Sciences & Biomedicine

LIVESTOCK

Microbiology

OUTBREAK

Science & Technology

TANZANIA

TRANSMISSION

WILDLIFE

Publication Status

Published

Date Publish Online

2023-11-14