Synthesis of phospho-amino acid analogues as tissue adhesive cement additives
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
In this paper we report the synthesis of a library of phospho-amino acid analogues, via a novel single-step allyl-phosphoester protection/Pd-mediated deprotection strategy. These phosphoserine and phosphotyrosine analogues were then applied as additives to create adhesive calcium phosphate cements, allowing us to probe the chemical origins of the increased surface binding strength. We demonstrate the importance of multiple calcium binding motifs in mediating adhesion, as well as highlighting the crucial role played by substrate hydrophobicity and orientation in controlling binding strength.
Date Issued
2020-02-26
Date Acceptance
2020-01-28
Citation
ACS Central Science, 2020, 6 (2), pp.226-231
ISSN
2374-7943
Publisher
American Chemical Society
Start Page
226
End Page
231
Journal / Book Title
ACS Central Science
Volume
6
Issue
2
Copyright Statement
© 2020 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Central Science, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acscentsci.9b01149.
Subjects
03 Chemical Sciences
Publication Status
Published
Date Publish Online
2020-02-11