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Escargot controls somatic stem cell maintenance through the attenuation of the insulin receptor pathway in Drosophila
File(s)
Author(s)
Demarco, Rafael Senos
Stack, Brian J
Tang, Alexander M
Voog, Justin
Sandall, Sharsti L
Type
Journal Article
Abstract
Adult stem cells coordinate intrinsic and extrinsic, local and systemic, cues to maintain the proper balance between self-renewal and differentiation. However, the precise mechanisms stem cells use to integrate these signals remain elusive. Here, we show that Escargot (Esg), a member of the Snail family of transcription factors, regulates the maintenance of somatic cyst stem cells (CySCs) in the Drosophila testis by attenuating the activity of the pro-differentiation insulin receptor (InR) pathway. Esg positively regulates the expression of an antagonist of insulin signaling, ImpL2, while also attenuating the expression of InR. Furthermore, Esg-mediated repression of the InR pathway is required to suppress CySC loss in response to starvation. Given the conservation of Snail-family transcription factors, characterizing the mechanisms by which Esg regulates cell-fate decisions during homeostasis and a decline in nutrient availability is likely to provide insight into the metabolic regulation of stem cell behavior in other tissues and organisms.
Date Issued
2022-04-19
Date Acceptance
2022-03-23
Citation
Cell Reports, 2022, 39 (3), pp.1-20
URI
URL
DOI
ISSN
2211-1247
Publisher
Elsevier
Start Page
1
End Page
20
Journal / Book Title
Cell Reports
Volume
39
Issue
3
Copyright Statement
© 2022 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
License URL
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000792114900005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
Subjects
Science & Technology
Life Sciences & Biomedicine
Cell Biology
SELF-RENEWAL
TISSUE HOMEOSTASIS
DIFFERENTIATION
SNAIL
GENES
TESTIS
EXPRESSION
GENETICS
HH
Publication Status
Published
Article Number
ARTN 110679
Date Publish Online
2022-04-19