Hydrogel optical fibers for continuous glucose monitoring
File(s)
Author(s)
Elsherif, Mohamed
Hassan, Muhammad Umair
Yetisen, Ali K
Butt, Haider
Type
Journal Article
Abstract
Continuous glucose monitoring facilitates the stringent control of blood glucose concentration in diabetic and intensive care patients. Optical fibers have emerged as an attractive platform; however, their practical applications are hindered due to lack of biocompatible fiber materials, complex and non-practical readout approaches, slow response, and time-consuming fabrication processes. Here, we demonstrate the quantification of glucose by smartphone-integrated fiber optics that overcomes existing technical limitations. Simultaneously, a glucose-responsive hydrogel was imprinted with an asymmetric microlens array and was attached to a multimode silica fiber's tip during photopolymerization, and subsequent interrogated for glucose sensing under physiological conditions. A smartphone and an optical power meter were employed to record the output signals. The functionalized fiber showed a high sensitivity (2.6 μW mM−1), rapid response, and a high glucose selectivity in the physiological glucose range. In addition, the fiber attained the glucose complexation equilibrium within 15 min. The lactate interference was also examined and it was found minimal ∼0.1% in the physiological range. A biocompatible hydrogel made of polyethylene glycol diacrylate was utilized to fabricate a flexible hydrogel fiber to replace the silica fiber, and the fiber's tip was functionalized with the glucose-sensitive hydrogel during the ultraviolet light curing process. The biocompatible fiber was quickly fabricated by the molding, the readout approach was facile and practical, and the response to glucose was comparable to the functionalized silica fiber. The fabricated optical fiber sensors may have applications in wearable and implantable point-of-care and intensive-care continuous monitoring systems.
Date Issued
2019-07-15
Date Acceptance
2019-05-01
Citation
Biosensors and Bioelectronics, 2019, 137, pp.25-32
ISSN
0956-5663
Publisher
Elsevier
Start Page
25
End Page
32
Journal / Book Title
Biosensors and Bioelectronics
Volume
137
Copyright Statement
© 2019 Elsevier B.V. All rights reserved.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000471359200004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biophysics
Biotechnology & Applied Microbiology
Chemistry, Analytical
Electrochemistry
Nanoscience & Nanotechnology
Chemistry
Science & Technology - Other Topics
Photonics
Fiber optics
Sensors
Continuous glucose monitoring
Boronic acids
INTENSIVE GLYCEMIC CONTROL
INSULIN THERAPY
BIOSENSOR
HYPERGLYCEMIA
MORTALITY
SENSOR
POLYMER
ACCORD
GEL
Publication Status
Published
Date Publish Online
2019-05-02