An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor
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Published version
Author(s)
Type
Journal Article
Abstract
Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses.
Date Issued
2016-01-14
Date Acceptance
2016-01-13
Citation
eLife, 2016, 5
ISSN
2050-084X
Publisher
eLife Sciences Publications
Journal / Book Title
eLife
Volume
5
Copyright Statement
© Dagdas et al. 2016. This
article is distributed under the
terms of the Creative Commons
Attribution License, which
permits unrestricted use and
redistribution provided that the
original author and source are
credited.
article is distributed under the
terms of the Creative Commons
Attribution License, which
permits unrestricted use and
redistribution provided that the
original author and source are
credited.
License URL
Sponsor
Biotechnology and Biological Sciences Research Council (BBSRC)
Grant Number
BB/M002462/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Biology
Life Sciences & Biomedicine - Other Topics
SELECTIVE AUTOPHAGY
CELL-DEATH
DISEASE RESISTANCE
SECRETORY PATHWAY
RXLR EFFECTORS
PLANT
RESPONSES
TRAFFICKING
ARABIDOPSIS
IMMUNITY
Irish potato famine
Nicotiana benthamiana
Phytophthora infestans
autophagy
effectors
infectious disease
late blight disease
microbiology
plant biology
Publication Status
Published
Article Number
10856