Elevated matrix metalloproteinases offer novel insight into their role in pediatric tuberculous meningitis
File(s)piy141.pdf (935.26 KB)
Published version
Author(s)
Li, Y
Wilkinson, Katalin Andrea
Wilkinson, Robert
Figaji, Antony
Rohlwink, Ursula Karin
Type
Journal Article
Abstract
We collected lumbar and ventricular cerebrospinal fluid and serum from 40 children treated for tuberculous meningitis and measured the concentrations of gelatinases and their inhibitors. The concentrations of matrix metalloproteinase 9 (MMP-9), MMP-2, tissue inhibitor of metalloproteinase 1 (TIMP-1), and TIMP-2 were significantly elevated in the lumbar CSF samples, and we found interesting dynamics for MMP-9 that offer novel insight into its role in pediatric patients with tuberculous meningitis.
Date Issued
2020-03-01
Date Acceptance
2018-12-10
Citation
Journal of the Pediatric Infectious Diseases Society, 2020, 9 (1), pp.82-86
ISSN
2048-7193
Publisher
Oxford University Press (OUP)
Start Page
82
End Page
86
Journal / Book Title
Journal of the Pediatric Infectious Diseases Society
Volume
9
Issue
1
Copyright Statement
© The Author(s) 2019. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor
Wellcome Trust
Grant Number
104803/Z/14/Z
Subjects
MMP-2
MMP-9
TIMP-1
TIMP-2
cerebrospinal fluid
matrix metalloproteinase
pediatric
tissue inhibitors of metalloproteinase
tuberculous meningitis
Publication Status
Published
Date Publish Online
2019-02-12