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  5. The Dynamics of Ascaris lumbricoides Infections
 
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The Dynamics of Ascaris lumbricoides Infections
OA Location
http://wrap.warwick.ac.uk/id/eprint/78671
Author(s)
Fowler, AC
Hollingsworth, TD
Type
Journal Article
Abstract
The Anderson–May model of human parasite infections and specifically that for the intestinal worm Ascaris lumbricoides is reconsidered, with a view to deriving the observed characteristic negative binomial distribution which is frequently found in human communities. The means to obtaining this result lies in reformulating the continuous Anderson–May model as a stochastic process involving two essential populations, the density of mature worms in the gut, and the density of mature eggs in the environment. The resulting partial differential equation for the generating function of the joint probability distribution of eggs and worms can be partially solved in the appropriate limit where the worm lifetime is much greater than that of the mature eggs in the environment. Allowing for a mean field nonlinearity, and for egg immigration from neighbouring communities, a negative binomial worm distribution can be predicted, whose parameters are determined by those in the continuous Anderson–May model; this result assumes no variability in predisposition to the infection.
Date Issued
2016-04-11
Date Acceptance
2016-03-29
Citation
Bulletin of Mathematical Biology, 2016, 78 (4), pp.815-833
URI
http://hdl.handle.net/10044/1/40709
DOI
https://www.dx.doi.org/10.1007/s11538-016-0164-2
ISSN
1522-9602
Publisher
Springer Verlag
Start Page
815
End Page
833
Journal / Book Title
Bulletin of Mathematical Biology
Volume
78
Issue
4
Copyright Statement
© Society for Mathematical Biology 2016
Subjects
Science & Technology
Life Sciences & Biomedicine
Biology
Mathematical & Computational Biology
Life Sciences & Biomedicine - Other Topics
Infectious diseases
Ascaris lumbricoides
Mathematical model
Negative binomial distribution
PARASITE POPULATION INTERACTIONS
TRANSMITTED HELMINTH INFECTIONS
STOCHASTIC TRANSMISSION
MODELS
CHEMOTHERAPY
STABILITY
DISEASE
HOOKWORM
FAMILIES
NUMBERS
Bioinformatics
01 Mathematical Sciences
06 Biological Sciences
Publication Status
Published
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