Quantitative approaches in clinical reproductive endocrinology
File(s)
Published version
OA Location
Author(s)
Type
Journal Article
Abstract
Understanding the human hypothalamic-pituitary-gonadal (HPG) axis presents a major challenge for medical science. Dysregulation of the HPG axis is linked to infertility and a thorough understanding of its dynamic behaviour is necessary to both aid diagnosis and to identify the most appropriate hormonal interventions. Here, we review how quantitative models are being used in the context of clinical reproductive endocrinology to: 1. analyse the secretory patterns of reproductive hormones; 2. evaluate the effect of drugs in fertility treatment; 3. aid in the personalization of assisted reproductive technology (ART). In this review, we demonstrate that quantitative models are indispensable tools enabling us to describe the complex dynamic behaviour of the reproductive axis, refine the treatment of fertility disorders, and predict clinical intervention outcomes.
Date Issued
2022-12-01
Date Acceptance
2022-09-27
Citation
Current Opinion in Endocrine and Metabolic Research, 2022, 27
ISSN
2451-9650
Publisher
Elsevier BV
Journal / Book Title
Current Opinion in Endocrine and Metabolic Research
Volume
27
Copyright Statement
© 2022 The Author(s). Published by Elsevier Ltd. This is an
open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
License URL
Sponsor
Engineering and Physical Sciences Research Council
Grant Number
EP/S023283/1
Publication Status
Published
Article Number
100421
Date Publish Online
2022-10-06