Induction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice and humans
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Published version
Author(s)
Type
Journal Article
Abstract
We compared live zebrafish, mouse and human nasal challenge responses to the TLR7/8 agonist resiquimod (R848). We found remarkably similar induction of mediators in the three species, offering novel mucosal models of innate anti-viral immunity.
Date Issued
2019-07-01
Date Acceptance
2019-04-03
Citation
Journal of Allergy and Clinical Immunology, 2019, 144 (1), pp.342-345.e7
ISSN
0091-6749
Publisher
Elsevier
Start Page
342
End Page
345.e7
Journal / Book Title
Journal of Allergy and Clinical Immunology
Volume
144
Issue
1
Copyright Statement
© 2019 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY li-cense (http://creativecommons.org/licenses/by/4.0/)
Sponsor
Imperial College Healthcare Trust Biomedical Research Centre (BRC)
Imperial College Healthcare NHS Trust- BRC Funding
Medical Research Council (MRC)
Medical Research Council (MRC)
National Institute for Health Research
Imperial College Healthcare NHS Trust- BRC Funding
Rosetrees Trust
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31002833
PII: S0091-6749(19)30518-4
Grant Number
P45058
RDA02
MR/R005982/1
MR/R005982/1
NF-SI-0513-10150
RDA06 79560
A442
Subjects
comparative cross-species analysis
mucosal innate immunity
nasal respiratory mucosa
resiquimod
vaccine adjuvants
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2019-04-16