Local accumulation times in a diffusion-trapping model of receptor dynamics at proximal axodendritic synapses
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Published version
Author(s)
Schumm, Ryan D
Bressloff, PC
Type
Journal Article
Abstract
The lateral diffusion and trapping of neurotransmitter receptors within the postsynaptic membrane of a neuron
play a key role in determining synaptic strength and plasticity. Trapping is mediated by the reversible binding
of receptors to scaffolding proteins (slots) within a synapse. In this paper we introduce a method for analyzing
the transient dynamics of proximal axodendritic synapses in a diffusion-trapping model of receptor trafficking.
Given a population of spatially distributed synapses, each of which has a fixed number of slots, we calculate
the rate of relaxation to the steady-state distribution of bound slots (synaptic weights) in terms of a set of local
accumulation times. Assuming that the rates of exocytosis and endocytosis are sufficiently slow, we show that
the steady-state synaptic weights are independent of each other (purely local). On the other hand, the local
accumulation time of a given synapse depends on the number of slots and the spatial location of all the synapses,
indicating a form of transient heterosynaptic plasticity. This suggests that local accumulation time measurements
could provide useful information regarding the distribution of synaptic weights within a dendrite.
play a key role in determining synaptic strength and plasticity. Trapping is mediated by the reversible binding
of receptors to scaffolding proteins (slots) within a synapse. In this paper we introduce a method for analyzing
the transient dynamics of proximal axodendritic synapses in a diffusion-trapping model of receptor trafficking.
Given a population of spatially distributed synapses, each of which has a fixed number of slots, we calculate
the rate of relaxation to the steady-state distribution of bound slots (synaptic weights) in terms of a set of local
accumulation times. Assuming that the rates of exocytosis and endocytosis are sufficiently slow, we show that
the steady-state synaptic weights are independent of each other (purely local). On the other hand, the local
accumulation time of a given synapse depends on the number of slots and the spatial location of all the synapses,
indicating a form of transient heterosynaptic plasticity. This suggests that local accumulation time measurements
could provide useful information regarding the distribution of synaptic weights within a dendrite.
Date Issued
2022-06
Date Acceptance
2022-05-18
Citation
Physical Review E, 2022, 105 (6)
ISSN
2470-0045
Publisher
American Physical Society (APS)
Journal / Book Title
Physical Review E
Volume
105
Issue
6
Copyright Statement
©2022 American Physical Society
Identifier
http://dx.doi.org/10.1103/physreve.105.064407
Publication Status
Published
Article Number
064407
Date Publish Online
2022-06-07