Venom‐derived bioactive peptides: from toxins to therapeutics
Author(s)
Sabu, Eldho
Al Musaimi, Othman
Type
Journal Article
Abstract
Venoms are complex biochemical mixtures composed of diverse bioactive components, including proteins, enzymes, small molecules, and peptides. Among these, venom-derived peptides have been evolutionarily optimized to interact with biological targets with exceptional potency and selectivity. Although historically regarded solely as toxic substances, these peptides have increasingly been recognized as valuable templates for therapeutic development. This review examines the structural and biochemical properties of venom-derived peptides, as well as their molecular targets, with particular emphasis on their applications in pain management and cardiovascular disorders. Key milestones in venom-based drug discovery are highlighted, from the approval of captopril in 1981 to more recent peptide candidates such as Hi1a and leptucin. Despite notable successes, the clinical translation of venom peptides remains constrained by challenges related to their physicochemical properties, including stability, bioavailability, and delivery. Emerging strategies aimed at overcoming these limitations are also discussed, underscoring advances in peptide engineering and drug delivery technologies. Overall, this review highlights the significant therapeutic potential of venom-derived peptides and their expanding role in the development of novel treatments for a wide range of pathological conditions.
Date Issued
2026-08-01
Date Acceptance
2026-08-08
Citation
Advanced Therapeutics, 2026, 9 (8)
ISSN
2366-3987
Publisher
Wiley
Journal / Book Title
Advanced Therapeutics
Volume
9
Issue
8
Copyright Statement
© 2026 The Author(s). Advanced Therapeutics published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Publication Status
Published
Article Number
e70166
Date Publish Online
2026-08-13