Designing DNA nanodevices for compatibility with the immune system of higher organisms
File(s)
Accepted version
Author(s)
Surana, S
Shenoy, AR
Krishnan, Y
Type
Journal Article
Abstract
DNA is proving to be a powerful scaffold to construct molecularly precise designer DNA devices. Recent trends reveal their ever-increasing deployment within living systems as delivery devices that not only probe but also program and re-program a cell, or even whole organisms. Given that DNA is highly immunogenic, we outline the molecular, cellular and organismal response pathways that designer nucleic acid nanodevices are likely to elicit in living systems. We address safety issues applicable when such designer DNA nanodevices interact with the immune system. In light of this, we discuss possible molecular programming strategies that could be integrated with such designer nucleic acid scaffolds to either evade or stimulate the host response with a view to optimizing and widening their applications in higher organisms.
Date Issued
2015-09-03
Date Acceptance
2015-06-26
Citation
Nature Nanotechnology, 2015, 10, pp.741-747
ISSN
1748-3395
Publisher
Nature Publishing Group
Start Page
741
End Page
747
Journal / Book Title
Nature Nanotechnology
Volume
10
Copyright Statement
Copyright © 2015, Rights Managed by Nature Publishing Group
Sponsor
The Royal Society
Wellcome Trust
Grant Number
RG130811
108246/Z/15/Z
Subjects
Science & Technology
Technology
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Science & Technology - Other Topics
Materials Science
SPHERICAL NUCLEIC-ACIDS
IN-VIVO STABILITY
LUPUS-ERYTHEMATOSUS
CYTOSOLIC DNA
GENE DELIVERY
PLASMID DNA
AIM2 INFLAMMASOME
EXONUCLEASE TREX1
NANOSCALE SHAPES
VIRAL-INFECTION
Animals
Biocompatible Materials
Cell Line
DNA
Drug Carriers
Drug Design
Humans
Immune System
Mice
Nanomedicine
Nanostructures
MD Multidisciplinary
Publication Status
Published