Earthquakes generate multi-directional ground motions, two components in the horizontal direction and one in the vertical. Nevertheless, the effect of vertical motion on site response analysis has not been the object of extensive research. The 2010/2011 Canterbury sequence of seismic events in New Zealand is a prime example among other earlier field observations strongly corroborating that the vertical acceleration may have a detrimental effect on soil liquefaction. Consequently, this study aims to provide insight into the influence of the input vertical motion on sand liquefaction. For this reason, two ground motions, with very different frequency contents, are used as the input excitations. Non-linear elasto-plastic plane strain fully coupled effective stress-based finite element analyses are conducted to investigate the occurrence of liquefaction in a hypothetical fully saturated Fraser River Sand deposit. The results indicate that the frequency content of the input motion is of utmost importance for the response of sands to liquefaction when the vertical loading is considered.