The heterotopic tracheal allograft as an animal model of obliterative bronchiolitis
Author(s)
Hele, DJ
Yacoub, MH
Belvisi, MG
Type
Journal Article
Abstract
Heterotopic tracheal allografts in small rodents have been shown to share many characteristics with the development of obliterative bronchiolitis (OB) in the clinic and therefore provide a suitable animal model for the study of OB. The model facilitates the examination of the pathogenesis of the disease and the elucidation of the cellular and molecular mechanisms involved in its development. The model provides a less technically demanding alternative to whole lung transplantation in small rodents and should lead to a speedier identification of new treatments that might prevent the development of post-transplantation OB in the clinic.
Date Issued
2001-04-05
Date Acceptance
2001-03-12
Citation
Respiratory Research, 2001, 2 (3), pp.169-183
ISSN
1465-993X
Publisher
BioMed Central
Start Page
169
End Page
183
Journal / Book Title
Respiratory Research
Volume
2
Issue
3
Copyright Statement
© BioMed Central Ltd 2001
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000169361500009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Respiratory System
Allograft
Model
Obliterative bronchiolitis
Rat
Trachea
Posttransplant airway obliteration
Fibroblast growth-factor
Nitric-oxide synthase
Lung-transplantation
Chronic rejection
Immunosuppressive agents
UP-regulation
Rat model
Class-II
Disease
Animals
Bronchiolitis Obliterans
Disease Models, Animal
Transplantation, Heterotopic
Cardiovascular Medicine And Haematology
Clinical Sciences
Publication Status
Published