Microneedle-mediated nanomedicine to enhance therapeutic and diagnostic efficacy
File(s)
Published version
Author(s)
Zuo, Yuyang
Sun, Rujie
Del Piccolo, Nuala
Stevens, Molly M
Type
Journal Article
Abstract
Nanomedicine has been extensively explored for therapeutic and diagnostic applications in recent years, owing to its numerous advantages such as controlled release, targeted delivery, and efficient protection of encapsulated agents. Integration of microneedle technologies with nanomedicine has the potential to address current limitations in nanomedicine for drug delivery including relatively low therapeutic efficacy and poor patient compliance and enable theragnostic uses. In this Review, we first summarize representative types of nanomedicine and describe their broad applications. We then outline the current challenges faced by nanomedicine, with a focus on issues related to physical barriers, biological barriers, and patient compliance. Next, we provide an overview of microneedle systems, including their definition, manufacturing strategies, drug release mechanisms, and current advantages and challenges. We also discuss the use of microneedle-mediated nanomedicine systems for therapeutic and diagnostic applications. Finally, we provide a perspective on the current status and future prospects for microneedle-mediated nanomedicine for biomedical applications.
Date Issued
2024-04-18
Date Acceptance
2024-03-26
Citation
Nano Convergence, 2024, 11
ISSN
2196-5404
Publisher
SpringerOpen
Journal / Book Title
Nano Convergence
Volume
11
Copyright Statement
© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which
permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the
original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or
other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line
to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory
regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this
licence, visit http://creativecommons.org/licenses/by/4.0/.
permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the
original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or
other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line
to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory
regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this
licence, visit http://creativecommons.org/licenses/by/4.0/.
License URL
Identifier
https://nanoconvergencejournal.springeropen.com/articles/10.1186/s40580-024-00421-w#article-info
Subjects
CANCER
CONTRAST AGENTS
DESIGN STRATEGIES
Diagnostics
Drug delivery
DRUG-DELIVERY SYSTEMS
GOLD NANOPARTICLES
LIPID NANOPARTICLES
LIPOSOMES
Materials Science
Materials Science, Multidisciplinary
Microneedle
Nanomedicine
Nanoscience & Nanotechnology
PHOTODYNAMIC THERAPY
Physical Sciences
PHYSICOCHEMICAL PROPERTIES
Physics
Physics, Applied
POLYMERIC MICELLES
Science & Technology
Science & Technology - Other Topics
Technology
Therapeutics
Publication Status
Published
Article Number
15
Date Publish Online
2024-04-18