Unraveling biochemical spatial patterns: machine learning approaches to the inverse problem of stationary Turing patterns
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Published version
Author(s)
Endres, Robert
Matas-Gil, Antonio
Type
Journal Article
Abstract
The diffusion-driven Turing instability is a potential mechanism for spatial pattern formation in numerous biological and chemical systems. However, engineering these patterns and demonstrating that they are produced by this mechanism is challenging. To address this, we aim to solve the inverse problem in artificial and experimental Turing patterns. This task is challenging since patterns are often corrupted by noise and slight changes in initial conditions can lead to different patterns. We used both least squares to explore the problem and physics-informed neural networks to build a noise-robust method. We elucidate the functionality of our network in scenarios mimicking biological noise levels and showcase its application using an experimentally obtained chemical pattern. The findings reveal the significant promise of machine learning in steering the creation of synthetic patterns in bioengineering, thereby advancing our grasp of morphological intricacies within biological systems while acknowledging existing limitations.
Date Issued
2024-06-21
Date Acceptance
2024-04-24
Citation
iScience, 2024, 27 (6)
ISSN
2589-0042
Publisher
Elsevier
Journal / Book Title
iScience
Volume
27
Issue
6
Copyright Statement
© 2024 The Authors. Published by Elsevier Inc.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
1
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
1
License URL
Identifier
https://www.sciencedirect.com/science/article/pii/S2589004224010447
Publication Status
Published
Article Number
109822
Date Publish Online
2024-04-29