Visualizing metabolites at the cellular level: advancements in 3-micron laser desorption mass spectrometry imaging
File(s)1283602 (2).pdf (1.1 MB)
Published version
Author(s)
Type
Conference Paper
Abstract
By combining high beam quality picosecond pulsed optical parametric amplifiers at 2.94 μm with Rapid Evap-
ortive Ionisation Mass Spectrometry (REIMS), we have demonstrated record spatial pixel resolutions for ambient
mass spectrometry (MS) imaging of < 10 μm. In this contribution, we introduce our work in this area, demon-
strating the platform workflow and highlighting recent results of metabolic imaging at the single cell resolution
level.
ortive Ionisation Mass Spectrometry (REIMS), we have demonstrated record spatial pixel resolutions for ambient
mass spectrometry (MS) imaging of < 10 μm. In this contribution, we introduce our work in this area, demon-
strating the platform workflow and highlighting recent results of metabolic imaging at the single cell resolution
level.
Editor(s)
Alfano, Robert R
Seddon, Angela B
Shi, Lingyan
Date Issued
2024-03-13
Date Acceptance
2024-01-01
Citation
Optical Biopsy XXII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 2024, 12836, pp.4-4
Publisher
SPIE
Start Page
4
End Page
4
Journal / Book Title
Optical Biopsy XXII: Toward Real-Time Spectroscopic Imaging and Diagnosis
Volume
12836
Copyright Statement
Copyright 2024 Society of Photo‑Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, and modification of the contents of the publication are prohibited.
Identifier
http://dx.doi.org/10.1117/12.3008405
Source
SPIE BiOS
Publication Status
Published
Start Date
2024-01-27
Finish Date
2024-02-01
Coverage Spatial
San Francisco, CA, USA