Quorum sensing in synthetic biology: a review
File(s)main.pdf (3.1 MB)
Accepted version
Author(s)
Boo, Alice Renée
Ledesma Amaro, Rodrigo
Stan, Guy-Bart
Type
Journal Article
Abstract
In nature, quorum sensing is one of the mechanism bacterial populations use to communicate with
their own species or across species to coordinate behaviours. For the last 20 years, synthetic biologists
have recognised the remarkable properties of quorum sensing to build genetic circuits responsive to
population density. This has led to progress in designing dynamic, coordinated and sometimes multicellular systems for bio-production in metabolic engineering and for increased spatial and temporal
complexity in synthetic biology. In this review, we highlight recent works focused on using quorum
sensing to engineer cell-cell behaviour.
their own species or across species to coordinate behaviours. For the last 20 years, synthetic biologists
have recognised the remarkable properties of quorum sensing to build genetic circuits responsive to
population density. This has led to progress in designing dynamic, coordinated and sometimes multicellular systems for bio-production in metabolic engineering and for increased spatial and temporal
complexity in synthetic biology. In this review, we highlight recent works focused on using quorum
sensing to engineer cell-cell behaviour.
Date Issued
2021-12
Date Acceptance
2021-08-30
Citation
Current Opinion in Systems Biology, 2021, 28, pp.1-14
ISSN
2452-3100
Publisher
Elsevier
Start Page
1
End Page
14
Journal / Book Title
Current Opinion in Systems Biology
Volume
28
Copyright Statement
© 2021 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Commission of the European Communities
Royal Academy Of Engineering
Biotechnology and Biological Sciences Research Council (BBSRC)
Identifier
https://www.sciencedirect.com/science/article/pii/S245231002100072X?via%3Dihub
Grant Number
766840
CiET1819\5
BB/T011408/1
Publication Status
Published
Date Publish Online
2021-09-09