Micro and nanoscale technologies in oral drug delivery
File(s)2020-Ahadian-ADDR-accepted.pdf (2.39 MB)
Accepted version
Author(s)
Type
Journal Article
Abstract
Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery could bypass the physiological barriers that limit the oral delivery of these therapeutics. Micro- and nanoscale technologies, with an unprecedented ability to create, control, and measure micro- or nanoenvironments, have found tremendous applications in biology and medicine. In particular, significant advances have been made in using these technologies for oral drug delivery. In this review, we briefly describe biological barriers to oral drug delivery and micro and nanoscale fabrication technologies. Micro and nanoscale drug carriers fabricated using these technologies, including bioadhesives, microparticles, micropatches, and nanoparticles, are described. Other applications of micro and nanoscale technologies are discussed, including the fabrication of devices and tissue engineering models to precisely control or assess oral drug delivery in vivo and in vitro, respectively. Strategies to advance translation of micro and nanotechnologies into clinical trials for oral drug delivery are mentioned. Finally, challenges and future prospects on further integration of micro and nanoscale technologies with oral drug delivery systems are highlighted.
Date Issued
2020-07-22
Online Publication Date
2021-07-22T23:01:27Z
Date Acceptance
2020-07-17
ISSN
0169-409X
Publisher
Elsevier
Start Page
37
End Page
62
Journal / Book Title
Advanced Drug Delivery Reviews
Volume
157
Copyright Statement
© 2020 Published by Elsevier B.V. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Medical Research Council (MRC)
British Heart Foundation
Identifier
https://www.sciencedirect.com/science/article/pii/S0169409X2030096X?via%3Dihub
Grant Number
MR/R015651/1
RE/18/4/34215
Subjects
Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Drug delivery devices
Micro and nanocarriers
Micro and nanoscale technologies
Oral drug delivery
Tissue models
SOLID LIPID NANOPARTICLES
VITAMIN-E-TPGS
ON-A-CHIP
COMPLEXATION POLYMER HYDROGELS
IN-VIVO EVALUATION
CONTROLLED-RELEASE
GELATIN MICROPARTICLES
SILICA NANOPARTICLES
MICROFLUIDIC SYSTEM
TARGETED DELIVERY
Drug delivery devices
Micro and nanocarriers
Micro and nanoscale technologies
Oral drug delivery
Tissue models
1115 Pharmacology and Pharmaceutical Sciences
Pharmacology & Pharmacy
Publication Status
Published
Date Publish Online
2020-07-22