On-probe neural interface ASIC for combined electrical recording and optogenetic stimulation
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Neuromodulation technologies are progressing from pacemaking and sensory operations to full closed-loop control. In particular, optogenetics—the genetic modification of light sensitivity into neural tissue allows for simultaneous optical stimulation and electronic recording. This paper presents a neural interface application-specified integrated circuit (ASIC) for intelligent optoelectronic probes. The architecture is designed to enable simultaneous optical neural stimulation and electronic recording. It provides four low noise (2.08 μVrms) recording channels optimized for recording local field potentials (LFPs) (0.1–300 Hz bandwidth, ± 5 mV range, sampled 10-bit@4 kHz), which are more stable for chronic applications. For stimulation, it provides six independently addressable optical driver circuits, which can provide both intensity (8-bit resolution across a 1.1 mA range) and pulse-width modulation for high-radiance light emitting diodes (LEDs). The system includes a fully digital interface using a serial peripheral interface (SPI) protocol to allow for use with embedded controllers. The SPI interface is embedded within a finite state machine (FSM), which implements a command interpreter that can send out LFP data whilst receiving instructions to control LED emission. The circuit has been implemented in a commercially available 0.35 μm CMOS technology occupying a 1.95 mm × 1.10 mm footprint for mounting onto the head of a silicon probe. Measured results are given for a variety of bench-top, in vitro and in vivo experiments, quantifying system performance and also demonstrating concurrent recording and stimulation within relevant experimental models.
Date Issued
2018-06-01
Date Acceptance
2018-05-15
Citation
IEEE Transactions on Biomedical Circuits and Systems, 2018, 12 (3), pp.576-588
ISSN
1932-4545
Publisher
Institute of Electrical and Electronics Engineers
Start Page
576
End Page
588
Journal / Book Title
IEEE Transactions on Biomedical Circuits and Systems
Volume
12
Issue
3
Copyright Statement
© 2018 IEEE. Translations and content mining are permitted for academic research only. Personal use is also permitted, but republication/
redistribution
requires IEEE permission. See http://www.ieee.org/publications
standards/publications/rights/index.html for more information
redistribution
requires IEEE permission. See http://www.ieee.org/publications
standards/publications/rights/index.html for more information
License URL
Sponsor
Wellcome Trust
Identifier
https://ieeexplore.ieee.org/document/8359402
Grant Number
BH134389
Subjects
Science & Technology
Technology
Engineering, Biomedical
Engineering, Electrical & Electronic
Engineering
Channelrhodopsin
implantable
neural interface
neural recording
optoelectrode
optogenetics
optrode
NEURONS IN-VIVO
FIELD POTENTIALS
CLOSED-LOOP
AMPLIFIER
CHANNELRHODOPSIN-2
ARRAY
DESIGN
SYSTEM
SOC
0903 Biomedical Engineering
0906 Electrical And Electronic Engineering
Electrical & Electronic Engineering
Publication Status
Published
Date Publish Online
2018-05-15