Visualising the membrane viscosity of porcine eye lens cells using molecular rotors
File(s)c6sc05369f.pdf (571.22 KB)
Published version
Author(s)
Type
Journal Article
Abstract
The plasma membranes of cells within the eye lens play an important role in metabolite transport within the avascular tissue of the lens, maintaining its transparency over the entire lifespan of an individual. Here we use viscosity-sensitive ‘molecular rotors’ to map the microscopic viscosity within these unusual cell membranes, establishing that they are characterised by an unprecedentedly high degree of lipid organisation.
Date Issued
2017-02-14
Date Acceptance
2017-02-14
Citation
CHEMICAL SCIENCE, 2017, 8 (5), pp.3523-3528
ISSN
2041-6520
Publisher
Royal Society of Chemistry
Start Page
3523
End Page
3528
Journal / Book Title
CHEMICAL SCIENCE
Volume
8
Issue
5
Copyright Statement
© 2017 The Royal Society of Chemistry. Open Access. This article is licensed under a
Creative Commons Attribution-NonCommercial 3.0 Unported Licence (https://creativecommons.org/licenses/by-nc/3.0/).
Creative Commons Attribution-NonCommercial 3.0 Unported Licence (https://creativecommons.org/licenses/by-nc/3.0/).
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (EPSRC)
Imperial College Trust
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000400553000026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
EP/I003983/1
EP/K030760/1
N/A
Subjects
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
PLASMA-MEMBRANE
LIPID ORDER
LIVE CELLS
FLUORESCENCE MICROSCOPY
NUCLEAR CATARACT
INNER MEMBRANE
PROBES
DIFFUSION
DOMAINS
SPORES
Publication Status
Published