Diabetes therapy podcast: real-world data for glucose sensing technologies in type 1 diabetes
File(s)s13300-022-01331-y.pdf (251.54 KB)
Published version
Author(s)
Oliver, Nick
Type
Journal Article
Abstract
For people living with type 1 diabetes (T1D), home glucose monitoring has evolved from occasional qualitative urine tests to frequently sampled continuous data providing hundreds of data points per day to inform optimal self-management. Continuous glucose monitoring technologies have a robust evidence base derived from randomized controlled trials (RCTs) over the last 20 years, and are now implemented in routine clinical practice, reflecting their clinical and cost effectiveness. However, while randomized studies are the gold standard, they can be slow to set-up, unrepresentative and do not provide data for efficacy in large, unselected populations. Real-world data can be responsive to rapid product cycles in technologies, provide a large, representative population, and have a lower regulatory burden. In this podcast we discuss the advantages and pitfalls of using real-world data to assess the efficacy of continuous glucose sensing technologies in people with T1D, with reference to examples of real-world data for real-time and intermittently scanned continuous glucose monitoring. Large datasets confirm the RCT data for real-time technologies and additionally provide data for work absenteeism and hospital admissions, as well as showing the impact of advanced technology features that can be difficult to assess in randomized studies. Real-world data for intermittently scanned monitoring also confirm the randomized controlled trial data, provide additional insights not shown in controlled study environments and highlight the importance of health equality. A mature real-world dataset for automated insulin delivery systems is now available and the future of glucose sensing is also discussed.
Date Issued
2023-01
Date Acceptance
2022-10-25
Citation
Diabetes Therapy, 2023, 14
ISSN
1869-6953
Publisher
Adis, Springer Healthcare
Journal / Book Title
Diabetes Therapy
Volume
14
Copyright Statement
© The Author(s) 2022 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.
License URL
Identifier
https://link.springer.com/article/10.1007/s13300-022-01331-y
Subjects
ADULTS
ASSOCIATIONS
AWARENESS
Clinical trials
Continuous glucose monitoring
Endocrinology & Metabolism
GLYCEMIC CONTROL
HYPOGLYCEMIA
INSULIN INJECTIONS
Intermittently scanned continuous glucose monitoring
Life Sciences & Biomedicine
MULTICENTER
Real-time continuous glucose monitoring
Real-world data
Science & Technology
TIME
Type 1 diabetes
Publication Status
Published
Date Publish Online
2022-11-25