Pesticide exposure and lung function: a systematic review and meta-analysis.
File(s)
Accepted version
Author(s)
Ratanachina, J
De Matteis, S
Cullinan, P
Burney, P
Type
Journal Article
Abstract
BACKGROUND: Epidemiological studies have reported associations between pesticide exposure and respiratory health effects, but the quantitative impact on lung function is unclear. To fill this gap, we undertook a systematic review of the available literature on the association between pesticide exposure and pulmonary function. AIMS: To examine all available literature regarding the relationship between occupational and environmental exposure to pesticides and lung function. METHODS: We searched MEDLINE, EMBASE and Web of Science databases to 1 October 2017 without any date or language restrictions using a combination of MeSH terms and free text for 'pesticide exposure' and 'lung function'. We included studies that met the criteria of our research protocol registered in PROSPERO, and we assessed their quality using a modified Newcastle-Ottawa scale. RESULTS: Of 2356 articles retrieved, 56 articles were included in the systematic review and pooled in meta-analyses for forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC), FVC and FEV1. There was tentative evidence that exposure to cholinesterase (ChE) inhibiting pesticides reduced FEV1/FVC and no evidence that paraquat exposure affected lung function in farmers. CONCLUSIONS: Respiratory surveillance should be enhanced in those exposed to ChE-inhibiting pesticides which reduced FEV1/FVC according to the meta-analysis. Our study is limited by heterogeneity between studies due to different types of exposure assessment to pesticides and potential confounders. Further studies with a more accurate exposure assessment are suggested.
Date Issued
2019-12-21
Date Acceptance
2019-12-01
Citation
Occupational Medicine, 2019, 70 (1), pp.14-23
ISSN
0962-7480
Publisher
Oxford University Press (OUP)
Start Page
14
End Page
23
Journal / Book Title
Occupational Medicine
Volume
70
Issue
1
Copyright Statement
© The Author(s) 2019. Published by Oxford University Press on behalf of the Society of Occupational Medicine.
All rights reserved. For Permissions, please email: journals.permissions@oup.com. This is a pre-copy-editing, author-produced version of an article accepted for publication in Occupational Medicine following peer review. The definitive publisher-authenticated version J Ratanachina, S De Matteis, P Cullinan, P Burney, Pesticide exposure and lung function: a systematic review and meta-analysis, Occupational Medicine, , kqz161 is available online at: https://doi.org/10.1093/occmed/kqz161
All rights reserved. For Permissions, please email: journals.permissions@oup.com. This is a pre-copy-editing, author-produced version of an article accepted for publication in Occupational Medicine following peer review. The definitive publisher-authenticated version J Ratanachina, S De Matteis, P Cullinan, P Burney, Pesticide exposure and lung function: a systematic review and meta-analysis, Occupational Medicine, , kqz161 is available online at: https://doi.org/10.1093/occmed/kqz161
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31863096
PII: 5682639
Subjects
Lung function
pesticides
systematic review
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2019-12-21