TaiNi: maximizing research output whilst improving animals' welfare in neurophysiology experiments
File(s)s41598-017-08078-8.pdf (10.7 MB)
Published version
Author(s)
Type
Journal Article
Abstract
Understanding brain function at the cell and circuit level requires representation of neuronal activity through multiple recording sites and at high sampling rates. Traditional tethered recording systems restrict movement and limit the environments suitable for testing, while existing wireless technology is still too heavy for extended recording in mice. Here we tested TaiNi, a novel ultra-lightweight (<2 g) low power wireless system allowing 72-hours of recording from 16 channels sampled at ~19.5 KHz (9.7 KHz bandwidth). We captured local field potentials and action-potentials while mice engaged in unrestricted behaviour in a variety of environments and while performing tasks. Data was synchronized to behaviour with sub-second precision. Comparisons with a state-of-the-art wireless system demonstrated a significant improvement in behaviour owing to reduced weight. Parallel recordings with a tethered system revealed similar spike detection and clustering. TaiNi represents a significant advance in both animal welfare in electrophysiological experiments, and the scope for continuously recording large amounts of data from small animals.
Date Issued
2017-08-14
Online Publication Date
2017-08-14
2017-08-31T08:12:23Z
Date Acceptance
2017-07-04
ISSN
2045-2322
Publisher
Nature Publishing Group
Journal / Book Title
Scientific Reports
Volume
7
Copyright Statement
© The Author(s) 2017. Open Access
This article is licensed under a Creative Commons Attribution 4.0 International
License, which permits use, sharing, adaptation, distribution and reproduction in any medium or
format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-
ative Commons license, and indicate if changes were made. The images or other third party material in this
article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the
material. If material is not included in the article’s Creative Commons license and your intended use is not per-
mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the
copyright holder. To view a copy of this license, visit
http://creativecommons.org/licenses/by/4.0/
This article is licensed under a Creative Commons Attribution 4.0 International
License, which permits use, sharing, adaptation, distribution and reproduction in any medium or
format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-
ative Commons license, and indicate if changes were made. The images or other third party material in this
article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the
material. If material is not included in the article’s Creative Commons license and your intended use is not per-
mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the
copyright holder. To view a copy of this license, visit
http://creativecommons.org/licenses/by/4.0/
Source Database
manual-entry
Subjects
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
MOUSE MODEL
MEMORY
UNIT
SUPPRESSION
RECORDINGS
OSCILLATION
RELIABILITY
RIPPLES
SLEEP
WAVES
Action Potentials
Animal Welfare
Animals
Behavior, Animal
Brain
Electrophysiological Phenomena
Electrophysiology
Female
Mice
Neurons
Neurophysiology
Wireless Technology
Brain
Neurons
Animals
Mice
Behavior, Animal
Electrophysiology
Neurophysiology
Action Potentials
Animal Welfare
Female
Electrophysiological Phenomena
Wireless Technology
Publication Status
Published
Article Number
8086
Date Publish Online
2017-08-14