Hypoxic regulation of neutrophil function and consequences for Staphylococcus aureus infection
Author(s)
Lodge, Katharine M
Thompson, AA Roger
Chilvers, Edwin R
Condliffe, Alison M
Type
Journal Article
Abstract
Staphylococcal infection and neutrophilic inflammation can act in concert to establish a profoundly hypoxic environment. In this review we summarise how neutrophils and Staphylococcus aureus are adapted to function under hypoxic conditions, with a particular focus on the impaired ability of hypoxic neutrophils to effect Staphylococcus aureus killing.
Date Issued
2017-03-01
Date Acceptance
2016-10-12
Citation
Microbes and Infection, 2017, 19 (3), pp.166-176
ISSN
1286-4579
Publisher
Elsevier
Start Page
166
End Page
176
Journal / Book Title
Microbes and Infection
Volume
19
Issue
3
Copyright Statement
© 2017 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000397077000004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
Microbiology
Neutrophil
Hypoxia
Staphylococcus aureus
EXTRACELLULAR TRAP FORMATION
INDUCIBLE FACTOR-I
SYSTEMIC HYPOXIA
CELL-DEATH
POLYMORPHONUCLEAR NEUTROPHILS
INFLAMMATORY RESPONSE
BACTERICIDAL CAPACITY
INTERMITTENT HYPOXIA
PMN PHAGOCYTOSIS
OXYGEN-TENSION
Publication Status
Published
Date Publish Online
2016-10-24