The pneumococcal divisome: dynamic control of streptococcus pneumoniae cell division
OA Location
Author(s)
Briggs, Nicholas S
Bruce, Kevin E
Naskar, Souvik
Winkler, Malcolm E
Roper, David I
Type
Journal Article
Abstract
Cell division in Streptococcus pneumoniae (pneumococcus) is performed and regulated by a protein complex consisting of at least 14 different protein elements; known as the divisome. Recent findings have advanced our understanding of the molecular events surrounding this process and have provided new understanding of the mechanisms that occur during the division of pneumococcus. This review will provide an overview of the key protein complexes and how they are involved in cell division. We will discuss the interaction of proteins in the divisome complex that underpin the control mechanisms for cell division and cell wall synthesis and remodelling that are required in S. pneumoniae, including the involvement of virulence factors and capsular polysaccharides.
Date Issued
2021-10-18
Date Acceptance
2021-09-15
Citation
Frontiers in Microbiology, 2021, 12, pp.1-13
ISSN
1664-302X
Publisher
Frontiers Media
Start Page
1
End Page
13
Journal / Book Title
Frontiers in Microbiology
Volume
12
Copyright Statement
© 2021 Briggs, Bruce, Naskar, Winkler and Roper. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000722852300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Microbiology
Streptococcus pneumoniae (pneumococcus)
cell division
peptidoglycan (PG) synthesis
FtsZ
antibiotic resistance
PENICILLIN-BINDING PROTEINS
PEPTIDOGLYCAN SYNTHESIS
DNA TRANSLOCATION
WILD-TYPE
FTSZ
MEMBRANE
IDENTIFICATION
REVEALS
PBP2B
GENE
Publication Status
Published
Article Number
ARTN 737396
Date Publish Online
2021-10-18