Sex and gender in glomerular disease.
File(s)
Published version
Author(s)
Beckwith, Hannah
Lightstone, Liz
McAdoo, Steve
Type
Journal Article
Abstract
There is increasing understanding that a multifaceted interplay of sex-dependent genetic and immune dysregulation underpins the development of glomerular disorders. Regional and ethnic variations in glomerular disease incidence make delineating the effects of sex and gender on disease pathophysiology more complex, but there is a marked paucity of research in this area. This review article presents a summary of the current understanding of sex and gender in glomerular disease, highlighting the broader effects of sex and gender on autoimmunity, clinical presentations, and pathophysiology of individual glomerular diseases, as well as exploring sex, gender, and glomerular disease within a wider socioenvironmental context. It is important to specifically consider the effects of sex and gender when presenting and analyzing clinical and scientific studies on glomerular disease. Failure to do so risks promoting disparities within health care provision, neglecting opportunities to identify sex-specific biomarkers, and potentially hindering the development of sex-specific therapies.
Date Issued
2022-03
Date Acceptance
2022-03-01
Citation
Seminars in Nephrology, 2022, 42 (2), pp.185-196
ISSN
0270-9295
Publisher
Elsevier
Start Page
185
End Page
196
Journal / Book Title
Seminars in Nephrology
Volume
42
Issue
2
Copyright Statement
© 2022 The Author(s). Published by Elsevier Inc. This is an open
access article under the CC BY license (http://creativecommons.
org/licenses/by/4.0/)
https://doi.org/10.1016/j.semnephrol.2022.04.008
access article under the CC BY license (http://creativecommons.
org/licenses/by/4.0/)
https://doi.org/10.1016/j.semnephrol.2022.04.008
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/35718365
PII: S0270-9295(22)00016-X
Subjects
Sex
autoimmunity
gender
glomerular disease
glomerulonephritis
Autoimmunity
Female
Glomerulonephritis
Humans
Incidence
Kidney Diseases
Kidney Glomerulus
Male
Publication Status
Published
Coverage Spatial
United States