Targeted delivery of DNA-Au nanoparticles across the blood-brain
barrier using focused ultrasound
barrier using focused ultrasound
File(s)
Accepted version
Accepted version
Author(s)
Chan, tiffany
Morse, sophie
Copping, mathew
Choi, james
Vilar Compte, R
Type
Journal Article
Abstract
Nanoparticles have been widely studied as versatile platforms for in vivo imaging and therapy. However, their use to image and/or treat the brain is limited, as they are often unable to cross the blood–brain barrier (BBB). To overcome this problem, herein we report the use of focused ultrasound in vivo to successfully deliver DNA‐coated gold nanoparticles to specific locations in the brains of mice.
Date Issued
2018-07-06
Date Acceptance
2018-05-09
Citation
ChemMedChem, 2018, 13 (13), pp.1311-1314
ISSN
1860-7187
Publisher
Wiley
Start Page
1311
End Page
1314
Journal / Book Title
ChemMedChem
Volume
13
Issue
13
Copyright Statement
© 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the accepted version of the following article, which has been published in final form at https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201800262.
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Grant Number
EP/J021199/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Chemistry, Medicinal
Pharmacology & Pharmacy
blood-brain barrier
brain
DNA
nanoparticles
ultrasound
GOLD NANOPARTICLES
DOXORUBICIN DELIVERY
GENE-REGULATION
NUCLEIC-ACIDS
MICROBUBBLES
SIZE
DNA
blood-brain barrier
brain
nanoparticles
ultrasound
Animals
Biological Transport
Blood-Brain Barrier
Carbocyanines
DNA
Drug Carriers
Drug Delivery Systems
Gold
Metal Nanoparticles
Mice
Particle Size
Ultrasonic Waves
Blood-Brain Barrier
Animals
Mice
Gold
Carbocyanines
DNA
Drug Carriers
Drug Delivery Systems
Biological Transport
Particle Size
Metal Nanoparticles
Ultrasonic Waves
Medicinal & Biomolecular Chemistry
0304 Medicinal and Biomolecular Chemistry
0305 Organic Chemistry
1115 Pharmacology and Pharmaceutical Sciences
Publication Status
Published
Date Publish Online
2018-05-09