Hierarchical binding of copperII to N-truncated Aβ4-16 peptide
File(s)c9mt00299e.pdf (2.02 MB) Supporting Information_Teng_etal.pdf (9.63 MB)
Published verison
Supporting information
Author(s)
Type
Journal Article
Abstract
N-Truncated Aβ4–42 displays a high binding affinity with CuII. A mechanistic scheme of the interactions between Aβ4–42 and CuII has been proposed using a fluorescence approach. The timescales of different conversion steps were determined. This kinetic mechanism indicates the potential synaptic functions of Aβ4–42 during neurotransmission.
Date Issued
2020-04-01
Date Acceptance
2020-02-18
Citation
Metallomics: integrated biometal science, 2020, 12 (4), pp.470-473
ISSN
1756-5901
Publisher
Royal Society of Chemistry
Start Page
470
End Page
473
Journal / Book Title
Metallomics: integrated biometal science
Volume
12
Issue
4
Copyright Statement
© The Royal Society of Chemistry 2020. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (https://creativecommons.org/licenses/by/3.0/)
Sponsor
The Leverhulme Trust
Biotechnology and Biological Sciences Research Council (BBSRC)
Identifier
https://pubs.rsc.org/en/content/articlelanding/2020/MT/C9MT00299E#!divAbstract
Grant Number
RPG-2015-345
BB/R022429/1
Subjects
03 Chemical Sciences
Analytical Chemistry
Publication Status
Published online
Date Publish Online
2020-04-01