The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
The short chain fatty acid (SCFA) propionate, produced through fermentation of dietary fibre by the gut microbiota, has been shown to alter hepatic metabolic processes that reduce lipid storage. We aimed to investigate the impact of raising colonic propionate production on hepatic steatosis in adults with non‐alcoholic fatty liver disease (NAFLD). Eighteen adults were randomised to receive 20g/day of an inulin‐propionate ester (IPE), designed to deliver propionate to the colon, or an inulin‐control for 42‐days in a parallel design. The change in intrahepatocellular lipid (IHCL) following the supplementation period was not different between groups (P=0.082), however IHCL significantly increased within the inulin‐control group (20.9±2.9 to 26.8±3.9%; P=0.012; n=9), which was not observed within the IPE group (22.6±6.9 to 23.5±6.8%; P=0.635; n=9). The predominant SCFA from colonic fermentation of inulin is acetate, which in a background of NAFLD and a hepatic metabolic profile that promotes fat accretion, may provide surplus lipogenic substrate to the liver. The increased colonic delivery of propionate from IPE appears to attenuate this acetate‐mediated increase in IHCL.
Date Issued
2019-08-01
Date Acceptance
2018-08-07
Citation
Diabetes, Obesity and Metabolism, 2019, 21 (2), pp.372-376
ISSN
1462-8902
Publisher
Wiley
Start Page
372
End Page
376
Journal / Book Title
Diabetes, Obesity and Metabolism
Volume
21
Issue
2
Copyright Statement
© 2018 Wiley. This is the accepted version of an article which has been published in final form at https://dx.doi.org/10.1111/dom.13500
Sponsor
Commission of the European Communities
Biotechnology and Biological Sciences Research Council (BBSRC)
Biotechnology and Biological Sciences Research Council (BBSRC)
National Institute for Health Research
Grant Number
289511
BB/H004971/1
BB/L004259/1
NF-SI-0513-10029
Subjects
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
clinical trial
dietary intervention
fatty liver
insulin resistance
DE-NOVO LIPOGENESIS
APPETITE REGULATION
HIGH-CARBOHYDRATE
ACID
OLIGOFRUCTOSE
INDIVIDUALS
MAINTENANCE
METABOLISM
clinical trial
dietary intervention
fatty liver
insulin resistance
1103 Clinical Sciences
Endocrinology & Metabolism
Publication Status
Published
Date Publish Online
2018-08-11